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Updated: Jun 13, 2025

Saccharomyces cerevisiae Metabolic Labeling with 4-thiouracil and the Quantification of Newly Synthesized mRNA As a Proxy for RNA Polymerase II Activity
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Saccharomyces cerevisiae Metabolic Labeling with 4-thiouracil and the Quantification of Newly Synthesized mRNA As a Proxy for RNA Polymerase II Activity

Published on: October 22, 2018

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线粒体RNA的细胞溶液泄漏驱动SASP

Stella Victorelli1,2, Madeline Eppard1,2, Seung-Hwa Woo1,2

  • 1Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

Research square
|September 11, 2024
PubMed
概括

衰老细胞中的线粒体RNA (mtRNA) 通过RNA传感器触发炎症,驱动衰老相关的分泌表型 (SASP). 抑制这种途径和BAX/BAK等关键蛋白质减少SASP,为衰老和MASH提供治疗潜力.

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