在发烧阶段的病毒载荷是否是登革热疾病严重程度的预测因素?
Shashika Dayarathna1, Heshan Kuruppu1, Tehani Silva1
1University of Sri Jayewardenepura.
Research square
|September 11, 2024
概括
在斯里兰卡的一项研究中,在早期登革热期间的病毒性血与疾病严重程度没有显著的相关性. 然而,登革热病毒血清型2 (DENV2) 感染与严重登革热出血性发烧的风险更高有关.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 关于病毒性病的程度和登革热的临床严重程度,存在相互矛盾的结果.
- 调查早期登革热病毒性病与疾病进展之间的关联至关重要.
研究的目的:
- 为了确定早期登革热疾病中的病毒血症是否预测了随后的临床疾病严重程度.
- 分析登革热病毒 (DENV) 血清型与疾病结果之间的关系.
主要方法:
- 在斯里兰卡科伦坡 (2017-2022) 实时PCR被用于检测和血清型DENV在362名病人在病后4天内出现.
- 每天对患者进行监测,并根据世卫组织的标准 (1997年和2009年) 将疾病的严重程度分类.
主要成果:
- 病毒载量和进展为登革热出血性发烧 (DHF) 或严重登革热 (SD) 之间没有发现显著的关联.
- 病毒载荷在DENV血清型之间有显著差异,其中DENV2显示最低,DENV3显示最高的病毒载荷.
- DENV2 感染与患 DHF 的风险增加显著相关 (OR 1.9).
结论:
- 发烧阶段的病毒血症水平似乎不能在这个斯里兰卡队列中显著预测临床疾病严重程度.
- DENV血清型是影响病毒载量的重要因素,DENV2对严重疾病的风险更高.
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