对外周围炎症标志物与未使用药物第一期精神分裂症中自杀风险之间的相关性评估
Ümit Haluk Yeşilkaya1,2, Meltem Şen1, Yasin Hasan Balcıoğlu1
1Department of Psychiatry, Bakirkoy Prof Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey.
Noro psikiyatri arsivi
|September 11, 2024
概括
炎症标志物与精神分裂症患者的自杀风险有关,尽管不是直接的预测因素. 自杀倾向患者的高度外周炎症可能源于自杀和精神疾病之间的联系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 精神分裂症患者的自杀行为 (SB) 比一般人群更高.
- 了解自杀的神经生物学和预测精神分裂症中的SB风险至关重要.
研究的目的:
- 研究与第一发精神分裂症 (FES) 患者自杀行为相关的外周炎症标志物.
- 探索精神分裂症炎症和自杀风险之间的关联.
主要方法:
- 血液中白细胞 (WBC),中性粒细胞,单细胞,白蛋白,C反应蛋白 (CRP) 的水平及其比率在FES患者和没有SB,非精神病患者与SB (NPS) 和健康对照 (HC) 中进行比较.
- 使用阳性和阴性综合征量表 (PANSS) 和哥伦比亚自杀严重程度评级量表 (CSSRS) 进行症状评估.
主要成果:
- 与HC相比,在所有患者组中都发现WBC,中性细胞,单细胞,白蛋白,CRP和中性细胞/白蛋白比率 (NAR) 的升高.
- 在NPS组中,CRP/白蛋白比率 (CAR) 是最高的,而单细胞/淋巴细胞比率 (MLR) 在FES患者中高于HC.
- 在SB (FES-S) 的FES患者和没有SB (FES-NS) 或NPS患者之间没有观察到炎症标志物的显著差异.
结论:
- 外周炎症与精神分裂症中自杀风险的程度有关,但不是试图的直接预测因素.
- 自杀和精神疾病之间的强烈联系可能解释了自杀患者的外周炎症升高.
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