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来自Selaginella tamariscina的氨基黄可以抑制SARS-CoV-2的RNA依赖RNA聚合酶

Kyoung Won Youn¹, Siyun Lee¹, Jang Hoon Kim²

¹Division of Biological Science and Technology, Yonsei University, Wonju, 26493, Republic of Korea.

|September 11, 2024

概括

新的研究确定了从草药植物*Selaginella tamariscina*提取物 (STE) 中提取的amintoflavone作为一种潜在的治疗方法. 阿门托弗拉抑制了SARS-CoV-2RNA依赖RNA聚合酶 (RdRp) 和病毒复制,为抗击冠状病毒变种提供了希望.

科学领域:

植物化学植物化学
病毒学病毒学
药物发现药物发现药物发现

背景情况:

持续存在的SARS-CoV-2变种威胁需要开发新的,可访问的治疗方法.
现有的疫苗和抗病毒药物面临着持续病毒演变的挑战,类似于流感.
草药提供了一个有前途的途径,用于识别新的化合物来应对新出现的病毒威胁.

研究的目的:

选草本植物提取物抑制SARS-CoV-2RNA依赖RNA聚合酶 (RdRp) 的化合物.
评估Selaginella tamariscina*提取物 (STE) 在抑制冠状病毒复制和降低细胞毒性的有效性.
为了确定STE中负责抗病毒活性的活性化合物.

主要方法:

对草药提取物进行查,以抑制SARS-CoV-2 RdRp活性.
在HCoV-OC43β冠状病毒模型上进行STE的体外测试,以评估复制抑制和细胞毒性.
从 STE.中识别和分离主要活性化合物.
确定化合物抑制SARS-CoV-2 RdRp和病毒复制的能力的验证.

主要成果:

*Selaginella tamariscina*提取物 (STE) 显示,SARS-CoV-2 RdRp活性显著降低.
STE治疗有效抑制了HCoV-OC43的复制,并减少了病毒诱导的细胞毒性.
胺托弗拉被确定为STE中的主要活性化合物,负责观察到的效应.
证实阿门托弗拉可以抑制SARS-CoV-2 RdRp和冠状病毒复制.

结论:

阿门托弗拉是Selaginella tamariscina*提取物中发现的一种化合物,对冠状病毒表现出强大的抗病毒活性.
这项研究突出了阿门托弗拉作为治疗SARS-CoV-2和相关冠状病毒疾病的治疗剂的潜力.
对阿门托弗拉的进一步研究可能会为未来的冠状病毒爆发带来有效和负担得起的治疗方法.

关键词:

阿门托弗拉 (Amentoflavone) 是一种含有氨基的药物.新冠病毒新冠病毒新冠病毒.植物植物植物植物植物.这种植物是 Selaginella tamariscina.

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