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在从未吸烟者中查肺癌

Gillianne G Y Lai^1,2, Daniel S W Tan^1,2,3

¹Division of Medical Oncology, National Cancer Centre Singapore.

Current opinion in oncology

|September 11, 2024

概括

低剂量计算机断层扫描 (LDCT) 肺癌查对从未吸烟者来说是有前途的,可以早期检测癌症. 风险分层是优化这一群体中最不发达国家治疗有效性的关键.

科学领域:

肺部病理学肺部病理学
在瘤学瘤学.
放射学放射学是一门学科.

背景情况:

低剂量计算机断层扫描 (LDCT) 的肺癌查已为吸烟者建立.
在从未吸烟者中,LDCT查的有效性和实施程度不太清楚.
吸烟者和不吸烟者之间,肺癌生物学有所不同,因此需要量身定制的查方法.

研究的目的:

审查LDCT对从未吸烟者肺癌查的新兴数据.
确定在从未吸烟者中进行LDCT查的实施挑战.

主要方法:

审查当前文献和有关从未吸烟者中LDCT查的新兴数据.
对从未吸烟者查研究中的肺癌检测率和特征的分析.
讨论风险预测模型和结节管理策略.

主要成果:

在高风险的从未吸烟者中进行的LDCT初步查研究显示,肺癌检测率是吸烟者试验的两倍.
由LDCT检测到的亚洲女性从未吸烟者的肺癌风险与男性一直吸烟者的风险相当.
大多数通过LDCT查发现的肺癌都是早期的 (0/1),引发了对过度诊断的担忧.

结论:

在不吸烟者中,使用适当的风险分层,LDCT查可能是有效的.
需要进一步的全球研究,以建立最佳的查策略,并评估广泛实施的健康/经济效益.

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