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Updated: Jun 26, 2026

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
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基于FRET的新型免疫突触生物传感器用于预测化学抗原受体-T细胞功能

Hae Nim Lee1,2, Soojin Lee3,4,5, Jisu Hong1,3

  • 1Department of Pharmacology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.

Small methods
|September 11, 2024
PubMed
概括

一个新的生物传感器通过评估免疫突触 (IS) 来评估嵌合抗原受体 (CAR) -T细胞功能. 这种工具通过优化IS质量而不是高亲和力来识别了具有改善癌症杀死能力的CAR变体,从而增强了CAR-T细胞疗法.

关键词:
费特·弗雷特 (FRET FRET) 是一家在美国的船只.仿制性抗原受体的仿制性抗原受体免疫学的突触.梅索他林是其中一种.scFv亲属关系 scFv亲属关系

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Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...