12周高强度间歇训练干预对COVID-19后心脏结构和功能的影响在12个月的随访后
Iben Elmerdahl Rasmussen1,2, Mathilde Løk2,3, Cody Garett Durrer1
1Centre for Physical Activity Research, University Hospital Copenhagen - Rigshospitalet, Copenhagen, Denmark.
Experimental physiology
|September 11, 2024
概括
高强度间歇训练 (HIIT) 在COVID-19幸存者的左心室质量 (LVM) 保存了12个月. 与标准护理相比,这种运动干预措施没有改善肺功能或减少症状严重程度.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 康复医学 康复医学 康复医学
背景情况:
- 之前因COVID-19住院治疗可能导致长期的心血管和肺部的后果.
- 高强度间歇训练 (HIIT) 已显示出在COVID-19后改善心脏功能方面的潜力.
- 在COVID-19幸存者中,HIIT对心脏结构,肺功能和症状的长期影响尚未得到充分证实.
研究的目的:
- 评估12周监督HIIT计划对之前因COVID-19住院的患者的左心室质量 (LVM) 的12个月影响.
- 评估HIIT对肺扩散能力,症状严重程度和12个月后续功能能力的影响.
主要方法:
- 研究人员盲目的随机对照试验比较监督HIIT (4x4分钟,每周3次) 与标准护理.
- 在基线和12个月随访时通过心脏磁共振成像 (cMRI) 评估的左心室质量 (LVM).
- 肺部对一氧化碳的扩散能力 (DLCO),症状严重程度 (PCFS) 和功能状态 (KBILD) 也被测量.
主要成果:
- 在HIIT组中维持了LVM,但在12个月后在标准护理组中没有 (平均差异9.68g,P=0.0182).
- 从基线到12个月的肺扩散容量 (DLCO) 变化中没有观察到群体之间的显著差异.
- 症状严重程度和功能状况在HIIT和标准护理组中同样有所改善.
结论:
- 一个为期12周的监督HIIT计划可以在12个月的随访中,在以前因COVID-19住院的个人中保持左心室质量.
- 与标准护理相比,研究的HIIT方案没有显示出对肺扩散能力或症状严重性的显著益处.
- 需要进一步的研究来探索最佳的运动干预措施,以在COVID-19后的患者中全面恢复.
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