自动腹膜透析与连续的门诊腹膜透析对患有功能衰竭的人
Esmee Driehuis1,2, Marga Eshuis3, Alferso Abrahams1
1Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, Netherlands.
The Cochrane database of systematic reviews
|September 11, 2024
概括
自动腹透析 (APD) 和持续的门诊腹透析 (CAPD) 没有足够的证据来确定在功能衰竭患者的优越性. 需要更多的大规模研究来比较它们的临床和患者报告的结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 脏替代疗法治疗 脏替代疗法
背景情况:
- 腹腔透析 (PD) 是一种针对功能衰竭的家庭替代疗法 (KRT).
- 存在两种主要方法:持续的门诊PD (CAPD) 和自动化的PD (APD).
- 人们越来越多地采用APD,因为人们认为它有好处,比如腹膜炎的发病率较低,心理社会接受度更好.
研究的目的:
- 在功能衰竭患者中比较APD和CAPD之间的临床和患者报告结果.
- 本综述更新了APD与CAPD在功能衰竭管理方面的先前证据.
主要方法:
- 搜索了科克伦脏和移植研究登记册,直到2024年8月.
- 包括随机对照试验 (RCT),比较APD与CAPD在患有功能衰竭的成年人.
- 使用随机效应元分析和GRADE方法来评估证据的确定性.
主要成果:
- 包括两个带有131名参与者的RCT.
- 有关APD与CAPD对死亡率,住院,腹膜炎,残留功能和生活质量的影响的证据非常不确定.
- 低至非常低的确定性证据在解释结果时需要谨慎.
结论:
- 目前的证据不足以指导临床实践在APD和CAPD之间进行功能衰竭的选择.
- 需要进行大规模的多中心研究,并进行适当的随访.
- 未来的研究应该集中在残留功能,液体平衡和患者报告的结果上.
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