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关于ADNI MRI 的概述
Clifford R Jack1, Arvin Arani1, Bret J Borowski1
1Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|September 11, 2024
概括
阿尔茨海默病神经成像计划 (ADNI) MRI核心提供了20年的标准化成像数据和定量分析. 这种宝贵的资源虽然未得到充分利用,但为神经退行性疾病研究提供了至关重要的见解.
科学领域:
- 神经成像是一种神经成像.
- 阿尔茨海默氏症疾病研究研究
- 数据科学数据科学数据科学
背景情况:
- 阿尔茨海默病神经成像计划 (ADNI) MRI核心已经运行了20年.
- 它为阿尔茨海默病研究提供了标准化的协议,精选的图像数据和定量措施.
研究的目的:
- 为了教育科学界关于ADNIMRI的方法和内容.
- 促进更多的认识,可访问性和ADNIMRI数据的利用.
主要方法:
- 标准化,多平台的MRI采集协议,随着时间的推移而优化.
- 来自各种MRI序列的精选图像数据 (例如,3D T1加权,FLAIR,dMRI).
- 定量分析包括FreeSurfer,基于张数的形态测量和白质超强度细分.
主要成果:
- 截至2024年4月25日,已有大量数据:超过17000张3DT1w图像和数千个其他系列.
- 许多定量分析是可访问的,FreeSurfer和基于张数的形态测量超过了10,000个数据集.
- ADNI MRI 数据集对研究界来说是一个严重未被充分利用的资源.
结论:
- ADNI MRI 核心已经发展了其协议,使其在 20 多年内保持当前状态.
- 研究人员可以使用大量的成像数据和定量测量数据库.
- 提高对ADNIMRI数据的认识和利用,可以促进神经退行性疾病研究.
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