在现场形成多聚合物葡萄糖反应性水凝
Sunita Saha1, Akbar Ali1, Saroj Saroj2
1Departments of Chemistry, Bioscience and Biomedical Engineering, Indian Institute of Technology-Bhilai, Durg, Chhattisgarh, 491002, India.
我们开发了一种简单的方法,用于创建可响应葡萄糖的多重聚合物凝,用于智能胰岛素输送. 这些新型水凝显示受控的胰岛素释放,可注射,自我愈合,无毒.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 响应刺激的水凝 (HGs) 是对智能药物递送有希望的.
- 具有葡萄糖反应的HG与酸 (PBA) 是在高血糖症中提供胰岛素的理想选择.
- 目前制造葡萄糖响应性HG的方法复杂,产生有限的胰岛素释放.
研究的目的:
- 开发一种简单的制造方法,用于对葡萄糖有反应的多重聚合物水凝 (MPHGs).
- 研究不同FPBA异构体对水凝特性和胰岛素释放的影响.
- 创建可注射,自我愈合和非细胞毒性葡萄糖反应矩阵用于药物输送.
主要方法:
- 在MPHG制造中使用了三组分现场混合方法.
- 采用异构功能型甲基乙酸 (FPBA) 交叉连接器连接聚乙醇 (PVA) 和分支聚乙烯胺 (PEI).
- 在凝过程中装载的分子载荷,如胰岛素.
主要成果:
- 成功制造出基于FPBA异构体的具有明显粘弹性特性的MPHG.
- 观察到对葡萄糖敏感的水凝溶解和货物释放,没有结构破坏.
- 4FPBA衍生的MPHGs显示了增强的固体状性质和更高的葡萄糖反应性胰岛素释放.
- 所有制造的MPHG都是可注射的,自我愈合的,在相关度下是无细胞毒性的.
结论:
- 开发了一种简单的方法来创建先进的葡萄糖反应敏捷的MPHGs.
- 证明了MPHG在控制和自我调节药物输送应用中的潜力.
- MPHGs为未来的体内研究和临床翻译提供了一个有前途的平台.
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