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相关概念视频

Dehydration Synthesis01:15

Dehydration Synthesis

Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.Synthesis of carbohydratesSugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from one reactant...
Hydrolysis01:15

Hydrolysis

Overview
Hydrolysis is a chemical reaction in which the addition of water breaks down a polymer into its simpler monomer units. For example, peptides break into amino acids, carbohydrates into simple sugars, and DNA into nucleotides. Enzymes often facilitate these processes.
Hydrolysis Reverses Dehydration Synthesis
Complex carbohydrates can be broken down by breaking the bonds between individual sugar units. The reaction breaks a glycosidic bond as water is added to the compound. The...
Precipitation Reactions03:10

Precipitation Reactions

In a precipitation reaction, aqueous solutions of soluble salts react to give an insoluble ionic compound – the precipitate. The reaction occurs when oppositely charged ions in solution overcome their attraction for water and bind to each other, forming a precipitate that separates out from the solution. Since such reactions involve the exchange of ions between ionic compounds in aqueous solution, they are also referred to as double displacement, double replacement, exchange reactions, or...
Aldehydes and Ketones with Water: Hydrate Formation01:20

Aldehydes and Ketones with Water: Hydrate Formation

An oxygen-based nucleophile, like water, can undergo addition reactions with aldehydes and ketones. The reaction leads to the formation of hydrates, also referred to as 1,1-diols or geminal diols.
The formation of hydrates is a reversible reaction. Hydrate formation is influenced by steric and electronic factors accompanying the alkyl substituents on the carbonyl group: The rate of hydrate formation increases with a decrease in the number of alkyl groups attached to the carbonyl carbon. Hence,...
Precipitation Processes01:12

Precipitation Processes

The experimental conditions in a gravimetric analysis should be optimized to maximize the particle size and purity of the obtained precipitate. Ideally, the concentration of the precipitating reagent should be low with effective stirring to maintain low relative supersaturation for the growth of large crystals. In homogeneous precipitation, the precipitant is slowly generated by a chemical reaction in the solution to avoid local reagent excesses. For example, urea decomposes gradually to...
Colloidal precipitates01:09

Colloidal precipitates

The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...

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相关实验视频

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The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
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The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

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在现场形成多聚合物葡萄糖反应性水凝.

Sunita Saha1, Akbar Ali1, Saroj Saroj2

  • 1Departments of Chemistry, Bioscience and Biomedical Engineering, Indian Institute of Technology-Bhilai, Durg, Chhattisgarh, 491002, India.

Chemistry, an Asian journal
|September 11, 2024
PubMed
概括

我们开发了一种简单的方法,用于创建可响应葡萄糖的多重聚合物凝,用于智能胰岛素输送. 这些新型水凝显示受控的胰岛素释放,可注射,自我愈合,无毒.

关键词:
葡萄糖对葡萄糖有反应的反应水凝是一种水凝.多重聚合物水凝是一种多重聚合物.智能胰岛素是一种智能胰岛素.在位置形成水凝.

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Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
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An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
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Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
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科学领域:

  • 生物材料科学 生物材料科学
  • 聚合物化学 聚合物化学
  • 药物输送系统 药物输送系统

背景情况:

  • 响应刺激的水凝 (HGs) 是对智能药物递送有希望的.
  • 具有葡萄糖反应的HG与酸 (PBA) 是在高血糖症中提供胰岛素的理想选择.
  • 目前制造葡萄糖响应性HG的方法复杂,产生有限的胰岛素释放.

研究的目的:

  • 开发一种简单的制造方法,用于对葡萄糖有反应的多重聚合物水凝 (MPHGs).
  • 研究不同FPBA异构体对水凝特性和胰岛素释放的影响.
  • 创建可注射,自我愈合和非细胞毒性葡萄糖反应矩阵用于药物输送.

主要方法:

  • 在MPHG制造中使用了三组分现场混合方法.
  • 采用异构功能型甲基乙酸 (FPBA) 交叉连接器连接聚乙醇 (PVA) 和分支聚乙烯胺 (PEI).
  • 在凝过程中装载的分子载荷,如胰岛素.

主要成果:

  • 成功制造出基于FPBA异构体的具有明显粘弹性特性的MPHG.
  • 观察到对葡萄糖敏感的水凝溶解和货物释放,没有结构破坏.
  • 4FPBA衍生的MPHGs显示了增强的固体状性质和更高的葡萄糖反应性胰岛素释放.
  • 所有制造的MPHG都是可注射的,自我愈合的,在相关度下是无细胞毒性的.

结论:

  • 开发了一种简单的方法来创建先进的葡萄糖反应敏捷的MPHGs.
  • 证明了MPHG在控制和自我调节药物输送应用中的潜力.
  • MPHGs为未来的体内研究和临床翻译提供了一个有前途的平台.