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在CD1小鼠模型中,两种化学/酶改性天然产品对活性亚托皮和系统性厌过症的潜在抗过敏活性
Gamal Ramadan1, Gehan Waheed1, Hend A Mohammed
1Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Immunological investigations
|September 11, 2024
概括
R-酸盐 (NaRLA) 和酶变异的异基 (EMIQ) 显示出显著的抗过敏作用. 这些天然产品的衍生物有效地防止巨细胞脱粒化,并保护小鼠模型免受致命的过敏反应.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
背景情况:
- 过敏反应是一种严重的,在全球范围内不断增加的过敏反应.
- 修改后的天然产品,R-酸盐 (NaRLA) 和酶修改后的异基 (EMIQ),以前被确定为潜在的巨细胞稳定剂.
- 需要进一步的研究来确认它们的治疗潜力.
研究的目的:
- 在IgE依赖性过敏症的小鼠模型中评估NaRLA和EMIQ的抗过敏活性.
- 为了比较NaRLA和EMIQ与硫沙拉 (SSZ) 的疗效,硫沙拉是一种已知的巨细胞稳定剂.
主要方法:
- 在卵素 (OVA) 诱导的活性皮肤过敏反应 (ACA) 和活性系统性过敏反应 (ASA) 挑战之前,小鼠先用NaRLA或EMIQ (50和100毫克/公斤) 进行口服治疗.
- 评估了血管透性,巨细胞脱粒化,组胺和介质蛋白-4水平以及他的病理学变化.
- 在ASA模型中记录了生存率.
主要成果:
- 与SSZ相似的NaRLA和EMIQ抑制了ACA中的血管透率的增加.
- 这两种药物都降低了ASA中的杆细胞脱粒化,腹膜组胺和介质素-4水平.
- 高剂量的EMIQ在70%的ASA小鼠中预防了死亡,表现优于SSZ.
结论:
- 在临床前模型中,NaRLA和EMIQ显示出显著的抗过敏作用.
- 这些化合物有效地抑制质细胞降粒和相关的炎症反应.
- NaRLA和EMIQ显示为对过敏反应的预防和治疗药物有前途.
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