尿路感染和早产风险:系统审查和元分析
Erping Wang1, Peng Tang1, Chen Chen1
1The First People's Hospital of Linping District, Urology Surgery, Hangzhou, Zhejiang Province, China.
Revista do Instituto de Medicina Tropical de Sao Paulo
|September 11, 2024
概括
患有尿路感染 (UTI) 的孕妇面临着近两倍的早产风险 (PTB). 早期发现和治疗尿路感染对于减少PTB和改善母亲和婴儿的结果至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 围产期健康 围产期健康
背景情况:
- 尿路感染 (UTI) 在怀孕期间很常见.
- 过早分娩 (PTB) 是一个重要的全球健康问题,严重的新生儿并发症.
研究的目的:
- 系统地审查和元分析妊娠尿路感染和PTB风险之间的关联.
- 量化孕妇患有尿路感染的孕妇PTB风险.
主要方法:
- 观察性研究的系统审查和元分析.
- 包括30项研究 (32个数据集) 与超过260万参与者.
- 随机效应模型用于估计95%置信区间 (CI) 的聚合赔率比率 (ORs).
主要成果:
- 在怀孕期间的尿路感染和PTB (OR,1.92;95% CI,1.62-2.27) 之间发现了显著的积极关联.
- 亚组分析证实了基于UTI和基于PTB的研究设计中的这种关联.
- 发现了出版偏差 (p=0.020) 和实质性的异质性 (I2=96.6%).
结论:
- 怀孕期间的尿路感染与早产风险增加密切相关.
- 早期发现和有效管理尿路感染对于缓解PTB至关重要.
- 需要进一步的研究来探索机制和有针对性的干预措施,考虑到潜在的偏见和异质性.
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