巴西妊娠期糖尿病患病率:系统性审查和元分析
Lucas Pitrez Mocellin1, Hewellynn de Azeredo Gomes1, Lincoln Sona1
1Universidade Federal do Pampa, Uruguaiana, Brasil.
Cadernos de saude publica
|September 11, 2024
概括
巴西妊娠期糖尿病的患病率为14%,远高于之前的估计. 这一系统性审查强调了区域差异以及诊断标准对流行率的影响.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 产科 产科 产科 产科 产科
背景情况:
- 孕期糖尿病 (GDM) 对母亲和婴儿的健康构成重大风险.
- 准确的流行数据对于巴西有效的公共卫生干预至关重要.
- 之前的巴西GDM患病率估计缺乏全面的,最新的系统审查.
研究的目的:
- 估计巴西妊娠期糖尿病的综合患病率.
- 根据偏差风险,诊断标准和地理区域分析GDM患病率.
- 通过系统性审查和元分析,提供国家一级的GDM流行情况概述.
主要方法:
- 从多个数据库和灰色文献中对2010-2021年间发表的研究进行系统审查.
- 使用强大的差异和随机效应模型进行元分析.
- 偏差风险的评估,异质性 (I2) 和出版偏差 (漏斗图,埃格尔测试).
主要成果:
- 在32项涉及21,942名女性的研究中,发现总体GDM患病率为14% (95%CI:11.0;16.0).
- 患病率因地区而异,东南地区为14%,中西部为9%.
- 使用国际妊娠糖尿病协会研究小组 (IADPSG) 标准的研究报告了15%的患病率.
结论:
- 这是关于巴西GDM患病率的首次全国系统审查,揭示了比预期更高的患病率.
- 研究之间存在相当大的异质性,受地区,诊断标准和研究质量的影响.
- 证据的整体GRADE确定性被评为低,需要进一步进行高质量的研究.
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