母亲暴露在Per-和多基基物质和后代染色体异常:日本环境和儿童研究
Kohei Hasegawa1,2, Noriko Motoki1,2, Yuji Inaba2,3,4
1Department of Preventive Medicine and Public Health, Shinshu University School of Medicine, Matsumoto, Japan.
Environmental health perspectives
|September 11, 2024
概括
孕产妇接触到和多醇基物质 (PFAS) 可能会增加后代染色体异常的风险. 像PFOS和PFNA这样的特定PFAS在这个大型出生队列研究中显示出了显著的关联.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 新兴的体外数据表明,和多基基物质 (PFAS) 可能会构成染色体异常的风险.
- 连接产前PFAS暴露与后代染色体异常的流行病学证据目前有限.
研究的目的:
- 调查 PFAS 产前暴露与后代染色体异常患病率之间的关联.
- 检查单个PFAS及其混合物对染色体异常风险的影响.
主要方法:
- 利用了来自日本环境和儿童研究的数据,这是一个全国性的出生队列.
- 采用后勤回归模型来评估第一季度母亲血PFAS度与两岁以下染色体异常之间的关联.
- 使用多重污染物模型分析PFAS混合物.
主要成果:
- 在24,724例出生 (17.8/10,000例出生) 中确定了44例染色体异常.
- 对 perfluorononanoic acid (PFNA) 和 perfluorooctane sulfonic acid (PFOS) 的暴露单独显示出与染色体异常的积极关联.
- 混合PFAS,其中PFOS和PFNA是主要的贡献者,也与风险增加有关.
结论:
- 研究结果表明,母亲暴露于PFAS,特别是PFOS,与后代染色体异常之间存在潜在联系.
- 由于从早期怀孕招募的潜在选择偏差,应谨慎解释结果.
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