在电刺激引起的肌肉损伤后,肌纤维损伤和巨细胞透的月经周期阶段差异
Brandon Pfeifer1, Briell King1, Mohadeseh Ahmadi1
1Department of Exercise Sciences, Brigham Young University, Provo, Utah, United States.
American journal of physiology. Endocrinology and metabolism
|September 11, 2024
概括
晚期卵泡期的女性在运动后会经历更多的肌肉损伤和较少的炎症. 这表明更高的雌激素水平可能会增加肌纤维损伤的易感性,并减少炎症反应.
科学领域:
- 运动生理学 运动生理学
- 骨肌肉生物学 骨肌肉生物学
- 内分泌学 在内分泌学.
背景情况:
- 月经周期影响各种生理过程,包括骨肌肉功能.
- 了解这些影响对于优化女性运动员的训练和恢复策略至关重要.
研究的目的:
- 研究月经周期阶段对肌纤维损伤,再生和电刺激 (ES) 诱导的肌肉损伤后的炎症的影响.
- 为了确定月经周期内的荷尔蒙波动是否会改变骨肌肉对损伤的反应.
主要方法:
- 28名绝经前妇女被分为早期毛囊 (EF) 和晚期毛囊 (LF) 阶段组.
- 在ES诱导的异常肌肉收缩之前和之后收集了肌肉活检和血清雌激素水平.
- 分析了肌肉损伤的标记物,肌纤维亡,再生,卫星细胞数量和巨细胞透.
主要成果:
- 与EF组相比,LF组的女性表现出较高的血清雌激素,并显示出较大的肌纤维衰老和再生.
- 尽管肌纤维损伤增加,但LF组经历了巨细胞透的减少.
- 虽然卫星细胞增殖发生在两组中,但在LF组中,最大同位体强度的恢复速度较慢.
结论:
- 高雌激素的晚期卵泡阶段与肌纤维损伤的易感性增加有关.
- 这一阶段也可能减轻随后的肌肉内炎症反应.
- 这些发现凸显了月经周期对骨肌肉对损伤反应的重大影响.
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