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侧部/尾部质突出部分对皮质的寡类细胞的贡献有限

Jialin Li¹, Feihong Yang², Yu Tian¹

¹State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, and Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.

|September 11, 2024

概括

皮层的寡腺细胞前代细胞 (OPCs) 不来自侧侧/尾尾突出 (LGE/CGE). 相反,中间质突出 (MGE) 是主要的来源,挑战了已建立的发育起源理论.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
细胞生物学细胞生物学

背景情况:

寡头质细胞对于脊椎动物的快速神经冲动传导至关重要.
皮层寡干细胞原生细胞 (OPCs) 传统上被认为源自多个胚胎来源,包括中间质突出 (MGE),横向/尾部质突出 (LGE/CGE) 和放射性质细胞 (RGCs).

研究的目的:

调查和挑战关于皮质OPCs发育起源的既定理解.
为了确定有助于皮质OPC群体的特定胚胎来源.

主要方法:

利用两个不同的命运映射策略来追踪OPC起源.
采用了Cre/loxP-依赖的排除策略,以消除特定的祖先种群.
执行了由MGE衍生的OPC的有针对性的切除.

主要成果:

证据强烈表明,LGE/CGE不会产生皮质OPCs.
消除MGE衍生的OPC导致皮质OPC群体的显著减少.
这些发现与之前关于LGE/CGE对皮质OPCs的贡献的观点相矛盾.

结论:

侧部/尾部状突出 (LGE/CGE) 不是皮质寡细胞原生细胞 (OPC) 的来源.
介质质突出 (MGE) 是皮层OPC发展的主要贡献者.
这项研究修订了对皮质OPC发育起源的理解,影响了对神经发育和疾病的研究.

关键词:

LGE LGE LGE LGE LGE LGE LGE LGE LGE LGE LGE LGE LGE LGE LGE LGE LGE MGE MGE 的意思是皮层皮层皮层发育生物学是发展生物学.绘制命运地图,绘制命运的地图移民移民迁移迁移这里是鼠标鼠标鼠标鼠标鼠标鼠标.神经科学神经科学一个小分子基细胞.

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