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COVID-19疫苗:过敏和焦虑:来自过敏病房的一个案例研究
Andrea R Teufelberger1, Andrada-Renata Dan2, Linda Irmler2
1Department of Dermatology and Venereology, Medical University of Graz, Auenbruggerplatz 8, 8036, Graz, Austria. andrea.teufelberger@medunigraz.at.
Wiener klinische Wochenschrift
|September 11, 2024
概括
对COVID-19疫苗的过敏反应的焦虑阻止了再接种疫苗. 用抗胰岛素进行前期治疗可以减少有过敏反应史的患者的反应严重程度和焦虑.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 在47名患者中研究了COVID-19疫苗接种后的立即过敏性症状.
- 评估29名已知的药物诱导过敏症患者对COVID-19疫苗或PEG和PS80等辅助剂的潜在敏感性.
- 在76名患者身上进行皮肤刺伤和皮内测试,主要使用PEG 2000和/或PS80.
研究的目的:
- 描述对COVID-19疫苗产生过敏反应的患者队列.
- 评估未来接种SARS-CoV-2疫苗的意愿.
- 确定关于再接种疫苗的决定背后的原因.
主要方法:
- 开发和管理一个问卷来评估患者的经验和决策.
- 分析了从报告过敏反应或寻求疫苗接种前测试的患者中填写的34个问卷.
- 使用疫苗成分和辅助剂进行皮肤试验 (刺伤和皮肤内试验).
主要成果:
- 大多数报告过敏反应的患者是女性 (40/7).
- 除了一名患者外,所有皮肤检测结果均为阴性,即使在使用COVID-19疫苗时也是如此.
- 由于担心反复出现过敏性反应,大多数患者都不愿再寻求进一步的COVID-19疫苗接种.
- 在74次疫苗接种中,用抗胰岛素进行前期治疗显著降低了过敏反应的严重程度.
结论:
- 患者对过敏反应期的焦虑是针对SARS-CoV-2的再接种疫苗的重要障碍.
- 抗胰岛素前期治疗和心理支持可以减轻敏感个体的过敏反应/过敏反应风险和焦虑.
- 建议过敏学家和心理学家之间进行合作,以管理因药物诱导的过敏反应和疫苗犹症的患者.
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