先进的食管胃结混合神经内分泌-非神经内分泌瘤与长期无复发生存
Shunsuke Takenaka1, Toshikatsu Tsuji2, Kenta Doden1
1Department of Gastrointestinal Surgery, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.
Surgical case reports
|September 11, 2024
概括
混合神经内分泌与非神经内分泌瘤 (MiNEN) 是一种罕见的癌症,预后不佳. 这项案例研究突出了一个患有食管胃结 MiNEN 的患者,在手术和化疗后实现了5.5年的无复发生存.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 混合神经内分泌与非神经内分泌瘤 (MiNEN) 是一种罕见的胃肠道恶性瘤.
- 由于频繁复发和转移,MiNEN往往呈现出不良的预后.
- 消化管-胃结 MiNEN (EGJ-MiNEN) 是一个特别罕见的亚型.
研究的目的:
- 报告一个长期无复发生存的EGJ-MiNEN病例.
- 讨论 MiNEN.EN 的管理和成果.
- 突出适当治疗可能带来有利结果的潜力.
主要方法:
- 一名患有EGJ腺癌的58岁男性患者接受了胸腔镜食道切除术.
- 病理诊断证实 pT3N2M0 阶段IIIA.
- 术后辅助性口服S-1化疗被使用.
主要成果:
- 患者实现了5.5年的无复发生存.
- 在术后6年被诊断出复发,转移扩散 (瘤,多流液,腹腔结节).
- 尸检和免疫组织化学证实了MiNEN复发,对神经内分泌标志物呈阳性.
结论:
- MiNEN通常具有不良的预后.
- 激进切除与辅助化疗相结合,可以在选择的MiNEN病例中导致长期无复发的生存.
- 这一案例凸显了对EGJ-MiNEN患者的警随访的重要性.
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