细胞性甲状腺癌和卵泡性甲状腺癌之间的预后比较:基于人口的倾向性得分匹配分析
Hao Peng1, He-Lin Ding2, Xiao-Lu Li1
1Jinling Hospital, Nanjing Medical University, No. 305, Zhongshan East Road, Xuanwu District, Nanjing, 210002, Jiangsu, China.
概括
细胞性甲状腺癌 (OTC) 患者与卵泡性甲状腺癌 (FTC) 患者相比,表现出明显的临床特征和较差的生存结果. 早期分化和量身定制的治疗策略对于改善细胞甲状腺癌预后至关重要.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 病理学 病理学 病理学
背景情况:
- 细胞性甲状腺癌 (OTC) 是一种罕见的甲状腺癌亚型,其复发率高于卵泡性甲状腺癌 (FTC).
- 有限的比较研究存在于OTC与FTC的临床病理特征和结果.
研究的目的:
- 为了比较瘤性甲状腺癌 (OTC) 和状甲状腺癌 (FTC) 的临床病理特征和生存结果.
- 确定影响OTC和FTC患者生存的预后因素.
主要方法:
- 对监测,流行病学和最终结果 (SEER) 数据库 (2004-2015) 的回顾性分析.
- 包括组织学诊断的OTC和FTC患者.
- 应用卡普兰-梅尔分析,倾向得分匹配 (PSM) 和考克斯回归模型.
主要成果:
- 分析了2329名OTC和5679名FTC患者的情况. OTC患者年龄较大,更有可能是白人,并且转移和多重瘤的发病率更高.
- 在PSM后,OTC患者的整体存活率 (OS) 和癌症特异性存活率 (CSS) 与FTC患者相比显著降低.
- 亚组分析显示,不同的人口和临床因素,不论年龄和甲状腺外延伸,OTC的OS和CSS都较差.
结论:
- 细胞性甲状腺癌 (OTC) 具有独特的临床特征,并且预后比卵泡性甲状腺癌 (FTC) 更差.
- 建议对OTC和FTC进行手术切除和放射性治疗.
- 早期区分和适当的治疗选择对于优化瘤细胞甲状腺癌的结果至关重要.
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