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介素-17和介素-23抑制剂是否会改变牛皮患者的凝血参数? :一个回顾性研究研究

Simge Ünal¹, Tuğcan Yüksek², Neslihan Demirel Öğüt¹

¹Faculty of Medicine, Department of Dermatology and Venereology, Uşak University, Uşak Training and Research Hospital, Uşak, Turkey.

Archives of dermatological research

|September 11, 2024

概括

一种IL-17抑制剂Secukinumab可能会在牛皮患者中缩短前热血素时间 (PT). IL-17和IL-23抑制剂通常显示出凝血安全性,但secukinumab需要监测.

科学领域:

皮肤病学皮肤病学
免疫学免疫学免疫学
心血管医学心血管医学

背景情况:

牛皮是一种慢性炎症性皮肤疾病,与全身炎症和心血管风险有关.
针对IL-17和IL-23通路的生物疗法对牛皮有效,但它们对凝血的影响需要评估.

研究的目的:

在接受IL-17抑制剂 (secukinumab,ixekizumab) 和IL-23抑制剂 (risankizumab,guselkumab) 治疗的牛皮患者中比较凝血参数,与未接受治疗的对照组进行比较.
评估这些生物制剂在血静功能方面的安全性.

主要方法:

对177名牛皮病患者病历的回顾性分析 (2019年1月至2023年3月).
患者被分类为控制组,seukinumab,ixekizumab,guselkumab和risankizumab组. 患者被分类为控制组,seukinumab,ixekizumab,guselkumab和risankizumab组. 患者被分类为控制组,seukinumab,ixekizumab,guselkumab和risankizumab组.
分析了凝血参数 (PT,aPTT,PLT,MPV,INR,纤维素原,D-二次体,B12).这些参数包括:

主要成果:

与对照组相比,secokinumab治疗与前热血素时间 (PT) 显著缩短相关 (p=0.002).
在所有治疗组中,没有观察到其他凝血参数的显著差异.
瑞桑基祖马布在凝血中没有显著的变化,这与一些文献相矛盾,这些文献表明大脑血管风险.

结论:

在牛皮患者的凝血参数方面,IL-17和IL-23抑制剂似乎通常是安全的.
塞库金纽马布对PT的作用表明它可能对凝血通路产生影响,需要监测.
进一步的长期研究至关重要,以充分阐明这些疗法的心血管影响.

关键词:

凝血的参数凝血的参数一个IL-17抑制剂.一个IL-23抑制剂.马斯 (Mace) 是一个子.输血组时间 (Prothrombin time) 是指输血组时间.牛皮是一种病.

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