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在前列腺癌中确定与昼夜钟相关的免疫预后指数和分子亚型

Lu Che¹, Dengxiong Li², Jie Wang²

¹Operating Room, Department of Anesthesiology, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, 610041, China.

Discover oncology

|September 11, 2024

概括

这项研究确定了与昼夜时钟 (CIC) 相关的分子亚型,并开发了前列腺癌 (PCa) 患者的预后指数. 与CIC相关的基因预后指数 (CICGPI) 准确预测治疗耐药性和患者的结果.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
时间生物学时间生物学

背景情况:

昼夜时钟 (CIC) 在瘤发生过程中起作用.
了解CIC对前列腺癌 (PCa) 的影响对于治疗分层至关重要.

研究的目的:

在PCa.中识别新的CIC介导分子亚型.
开发和验证PCa患者进行激进前列腺切除术 (RP) 或放射治疗 (RT) 的基因预后指数.
探索CICGPI与瘤免疫微环境之间的关系.

主要方法:

分析TCGAPCa数据以识别差异表达基因 (DEGs).
使用聚类和生存分析开发CIC相关的基因预后指数 (CICGPI).
在多个外部数据集上验证CICGPI,并评估其对化疗和放射电阻的诊断准确性.

主要成果:

根据TOP2A,APOE和ALDH2确定了两种PCa亚型,其中集群2显示出更高的生化复发 (BCR) 风险.
经过验证的CICGPI显示出显著的预后价值和高准确度来预测化学阻力 (AUC:0.781) 和辐射阻力 (AUC:0.988).
在癌症相关纤维细胞 (CAF) 和CICGPI得分之间发现了正相关性,高CAF密度与较差的BCR无生存率有关.

结论:

已确定的CIC相关的分子亚型和PCa.的免疫预后指数 (CICGPI).
在临床实践中,CICGPI对风险分层和治疗指导具有潜在的有用性.

关键词:

循环节的时钟是循环节的时间.分子子类型分子子类型前列腺癌是什么意思前列腺癌是什么意思瘤免疫环境瘤免疫环境

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