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Updated: Jun 13, 2025

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model
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通过整合多omics识别线粒体功能障碍和膝关节骨关节炎之间的遗传关联:基于数据的孟德尔随机化研究的摘要

Jiale Xie1, Rui Ma1, Xin Xu1

  • 1Department of Joint Surgery, HongHui Hospital, Xian Jiaotong University, Xian, Shaanxi, China.

Clinical rheumatology
|September 11, 2024
PubMed
概括

这项研究揭示了线粒体功能障碍和膝关节骨关节炎 (KOA) 之间的遗传联系. 特定的线粒体基因AKAP10和IMMP2L与KOA风险有显著的关联,提供了潜在的新治疗点.

关键词:
贝叶斯的局部化分析.膝关节骨关节炎是一种关节炎.门德尔的随机化线粒体功能障碍 线粒体功能障碍定量性特征位置 (loci loci) 是一个定量性特征位置.治疗目标 治疗目标

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