藻类类消费会改变羊带血管系统中血清素受体诱导的血管活性
James L Klotz1, Jessica L Britt2, Maslyn A Greene2
1USDA-ARS, Forage-Animal Production Research Unit, Lexington, KY, USA.
Human & experimental toxicology
|September 11, 2024
概括
来自受感染高的藻类化物降低动脉血管活性,影响胎儿的生长. 动脉中的5-HT2A受体是这种效果的关键,与5-HT1B/1D受体不同.
科学领域:
- 生殖生理学 生殖生理学
- 药理学 药理学是指药理学的学科.
- 围产儿医学 围产儿医学
背景情况:
- 在孕期晚期消费的藻类可以降低出生体重.
- 血管效应与血清激素和上腺体受体有关.
- 带血管活性对于胎儿发育至关重要.
研究的目的:
- 为了评估血清素 (5-HT) 受体5-HT2A和5-HT1B/1D在绵羊动脉和静脉中的血管活性.
- 为了确定从内菌感染的高菌中接触藻类对这些受体的影响.
- 为了研究特定的5-HT受体在藻类化物诱导的子宫内生长限制中的作用.
主要方法:
- 动脉和静脉从母羊中收集,这些母羊在怀孕的第110日和第133日被养了受内菌感染的 (E+) 或对照 (CON) 高矮子种子.
- 血管组织的部分暴露于5-HT1B/1D和5-HT2A受体激活剂度的增加.
- 测量了动脉和静脉的收缩反应.
主要成果:
- 5-HT1B/1D激动剂没有诱导带血管的收缩反应.
- 5-HT2A激动剂在动脉中刺激了显著的收缩反应,在d-110.10时的幅度更大.
- 来自CON羊的动脉在两个时间点显示出比E+羊更大的收缩反应;静脉显示出基于妊娠和治疗的差异性反应.
结论:
- 动脉和静脉中的血管收缩是由5-HT2A受体活性介导的.
- 动脉5-HT2A受体活性对受感染的高的藻类类暴露敏感.
- 变化的动脉5-HT2A受体活性可能是ergot类化合物诱导的子宫内生长限制的基础.
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