在生物医学应用中强大的组织粘附性:增强可注射蛋白质基水凝中的聚合物稳定性
Pijush Giri1, Daman Yadav1, Balaram Mishra1
1Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela, Odisha, India.
Journal of biomaterials science. Polymer edition
|September 11, 2024
概括
使用BSA-凝和THPC的基于蛋白质的新型水凝为生物医学应用提供了增强的机械强度和组织粘附性. 这种生物相容和可注射材料与传统组织粘合剂相比,表现优越.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 聚合物化学 聚合物化学
背景情况:
- 基于蛋白质的水凝由于生物相容性和生物降解性,对治疗药物具有吸引力.
- 现有的水凝往往有不良的机械性能,短暂的附着性和有限的生物相容性.
- 需要先进的水凝,提高机械强度和组织粘附性,用于生物医学应用.
研究的目的:
- 开发一种新的,坚固的,生物相容的基于蛋白质的水凝,用于组织粘附.
- 评估新的水凝的机械性能,组织粘附强度和生物相容性.
- 评估这种水凝作为现有组织粘合剂的优质替代品的潜力.
主要方法:
- 从牛血清白蛋白 (BSA) 和凝制成一个由两部分组成的水凝.
- 使用Tetrakis (基) 化 (THPC) 交叉连接了蛋白质溶液.
- 具有特征的机械性质 (抗拉强度,抗压强度),组织粘附性,细胞活力 (L929细胞) 和凝时间.
主要成果:
- 这种BSA-凝水凝具有很高的抗拉强度 (73.33 ± 11.54 KPa) 和压力强度 (173 KPa在75%应变下).
- 达到18.29 ± 2.22 kPa的最大组织粘附强度,超过了纤维素粘合剂.
- 与L929细胞 (97.09 ± 6.07%的活力) 和快速凝 (1.25 ± 0.17分钟) 证明了出色的生物相容性.
结论:
- 开发的BSA-凝水凝具有显著增强的机械和粘合性能.
- 水凝是生物相容,可注射,在生理条件下表现出快速凝.
- 这种基于蛋白质的新型水凝显示出作为生物医学行业中先进的组织粘合剂的巨大潜力.
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