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痛苦的链条:不断增加的入侵性A组链球菌病
Kimberly Davis1,2,3, Yara-Natalie Abo1,3,4, Andrew C Steer1,3,4
1Tropical Diseases Research Group, Murdoch Children's Research Institute.
Current opinion in infectious diseases
|September 11, 2024
概括
侵袭性A型 estreptococcal (GAS) 疾病在全球流行后急剧增加,这是由一种高病毒性菌株驱动的. 疫苗对于长期控制至关重要,因为目前的治疗方法仍然是经验性的.
科学领域:
- * 传染病流行病学
- * 微生物学 微生物学
- * * 公共卫生 公共卫生
背景情况:
- *在COVID-19大流行之前,A型链球菌 (GAS) 侵袭性疾病的发病率在全球范围内不断上升.
- * 自2022年中期以来,全球报告的IGAS病例的流行后激增.
- * 同时观察到红热,喉炎和病毒共感染的增加.
研究的目的:
- *描述最近全球侵袭性A型 estreptococcal (GAS) 疾病的流行病学.
- * 调查iGAS激增的近距离和远距离原因.
- *强调临床管理中的知识差距,并讨论预防策略.
主要方法:
- * 全球流行病学数据对侵袭性A型 estreptococcal (GAS) 疾病的分析.
- *对新出现的GAS传输动态数据的审查.
- *评估当前的临床管理实践和疫苗开发状态.
主要成果:
- * 一种高毒的M1英国菌株成为iGAS的重要原因,特别是在高收入国家.
- * 在侵袭性GAS分离物中报告的宏化物和林科萨米德耐药性的增加.
- * 有限的临床证据支持在严重的GAS感染中使用静脉注射免疫球蛋白.
- *针对GAS的疫苗开发仍处于早期阶段.
结论:
- * 在全球范围内,自2022年中期以来,iGAS费率在全球范围内升,这是由于疫情控制措施.
- * 占主导地位的高病毒性菌株是关键因素,但并不是这种激增的唯一解释.
- *iGAS的临床管理在很大程度上是经验性的,新数据有限.
- * 疫苗开发是可持续降低iGAS负担的最有前途的战略.
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