对早期衰老生物标志物和与坐着时间和体力活动相关联的双重驱动分析
Ryan Bruellman1, Shandell Pahlen2,3, Jarrod M Ellingson3,4
1Department of Genetics, Genomics and Bioinformatics, University of California Riverside, Riverside, California, United States of America.
PloS one
|September 11, 2024
概括
充满活力的体力活动可以抵消长时间坐着对健康的一些负面影响,可能会使个人在生物学上看起来更年轻. 减少坐着的时间对于保持健康和打击加速衰老至关重要.
科学领域:
- 老年学是指老年学的学科.
- 公共卫生 公共卫生
- 运动科学 运动科学
背景情况:
- 当前的体育活动指南可能无法充分解决日益增长的久坐行为.
- 身体活动对于健康的衰老至关重要,但其与坐时间的相互作用需要进一步研究.
- 了解活动强度和静坐如何影响健康对于对抗加速衰老至关重要.
研究的目的:
- 检查身体活动强度和坐姿行为如何影响健康结果.
- 为了确定身体活动可以在多大程度上减轻长时间坐着的不良影响.
- 通过共同双胞胎控制方法探索坐着和体育活动之间的权衡.
主要方法:
- 来自科罗拉多州采用/双胞胎研究28-49岁成年人的寿命行为发展和认知衰老 (CATSLife) 的数据分析.
- 使用线性混合效应模型来评估体重指数 (BMI) 和总胆固醇/高密度脂蛋白比率 (TC/HDL).
- 采用共同双胞胎控制方法来研究坐着和体力活动之间的相互作用.
主要成果:
- 长时间的坐着和充满活力的活动与TC/HDL和BMI的年龄趋势增加呈反向关联.
- 每天30分钟的剧烈炼与TC/HDL和BMI估计相似,与分别比5岁和10岁年轻的久坐不动的人相似.
- 共同双胞胎分析表明,积极的活动可能部分抵消与坐着相关的健康影响,尽管回报率正在下降.
结论:
- 长时间的坐着和体力活动对心血管和代谢健康指标产生相反的影响.
- 充满活力的体力活动可以在减轻长时间坐着所带来的不良健康影响方面发挥补偿作用.
- 公共卫生策略应整合减少坐着时间和增加积极活动的指导方针,以促进健康和打击加速衰老.
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