帕金森病中母音空间的变化:与认知和运动障碍的关联
Ginige S DeSilva1, Prashasti Upadhyay1, Michelle Manxhari2
1University of Massachusetts Chan Medical School, Worcester.
Journal of speech, language, and hearing research : JSLHR
|September 11, 2024
概括
认知障碍,而不是运动严重程度,在患有帕金森病 (PwP) 的患者中显著影响着母音发音. 在语音任务中,元音空间的变化有所不同,这凸显了认知在语音产生中的作用.
科学领域:
- 神经学 神经学
- 语音语言病理学 语言病理学
- 声学 声学 在声学方面
背景情况:
- 帕金森病 (PwP) 经常导致语言障碍,特别是在母音发音方面.
- 认知状态和特定的语音任务对PwP中母音空间可变性的影响尚不清楚.
研究的目的:
- 调查认知障碍 (轻度认知障碍 - MCI) 和语音任务类型如何影响PwP中的母音发音.
- 在PwP中探索母音空间,认知状态和运动症状严重程度之间的关系.
主要方法:
- 48名患有帕金森病 (PwP) 的人和15名对照人进行了持续的发音,阅读和图片描述任务.
- PwP被分为正常认知 (PD-NC) 或MCI (PD-MCI) 组.
- 声母发音指数 (VAI) 使用线性混合模型进行分析,并根据临床特征和运动得分进行调整 (MDS-UPDRS Part III).
主要成果:
- 与PD-NC组相比,PD-MCI组在所有任务中表现出明显较低的平均VAI.
- 与阅读或图片描述相比,所有参与者在持续的发音过程中都显示出减少的VAI.
- 运动症状严重程度 (MDS-UPDRS Part III) 并没有显著影响母音空间的变化.
结论:
- 认知障碍和语音任务类型是影响PwP中母音空间变化的关键因素.
- 这些发现表明,有可能开发基于语音的神经退行性疾病的生物标志物.
- 在评估PwP认知或运动缺陷时,语音任务选择至关重要.
相关概念视频
Parkinson's Disease: Overview
498
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
498
Parkinson's Disease: Treatment
237
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
237
Neural Regulation
39.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.2K
Alzheimer's Disease: Overview
452
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
452
Prosopagnosia
145
Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
145
Variability: Analysis
133
Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
The range is a simple measure of variability, indicating the difference between the highest and...
133


