高度尾癌的突变特征和瘤微环境变化,用代性高热内化疗治疗
David G Su1, Ankit Dhiman2, Varun V Bansal1
1Division of Surgical Oncology, Yale School of Medicine, New Haven, CT.
JCO precision oncology
|September 11, 2024
概括
对于带有腹膜转移的高度尾腺癌,高温腹膜内化疗 (HIPEC) 揭示了新的突变特征. 在HIPEC后T细胞的PD-L1增加与更好的无进展生存 (PFS) 相对应.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 高度尾腺癌 (HGAA) 与腹膜转移 (PMs) 有一个糟糕的预后.
- 超热性腹膜内化学疗法 (HIPEC) 是无法切除的HGAA-PM的治疗选择.
- HIPEC对HGAA-PM的免疫基因影响尚不清楚.
研究的目的:
- 在HIPEC之后探索HGAA-PM中的免疫基因组变化.
- 为了确定与HIPEC治疗结果相关的突变特征和免疫细胞种群.
主要方法:
- 从HGAA患者的79个转移性腹膜瘤沉积物的全外体测序,RNA测序和免疫分析.
- 在HIPEC前后对瘤活检的分析,以检测突变特征和免疫群体.
主要成果:
- 分析了15名患有HGAA-PM的患者.
- 通常发生突变的基因包括MUC16,MUC3A,MUC5AC和TTN.
- 突变特征 (SBS29,DBS11) 是普遍存在的.
- 在CD8+T细胞上更高的PD-L1同表达与改善的无进展生存率 (PFS) 相关,无论是内还是边缘 (P=.019,P=.025).
结论:
- 在HGAA-PM.中,HIPEC会诱导特定的突变特征.
- 在HIPEC后增加的PD-L1+细胞毒性T细胞种群与更好的PFS有关.
- 这些发现为HGAA-PM患者治疗HIPEC的预后提供了洞察力.
更多相关视频
00:08Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
Published on: August 24, 2019
9.9K
09:19Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
Published on: December 9, 2022
1.7K
相关概念视频
Appendicitis-I: Introduction
94
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
94
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Adaptive Mechanisms in Cancer Cells
5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
Appendicitis-II: Diagnostic Studies and Management
69
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
69
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
