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乳腺的分泌性癌症:放射学-病理学相关性

Pamela Boustros¹, Lilia Maria Sanchez², Louis Gaboury²

¹Department of Radiology, University of Montreal, Montreal, QC, Canada.

Journal of breast imaging

|September 11, 2024

概括

分泌性癌瘤是一种罕见的侵入性乳腺癌,通常呈现为缓慢生长的块. 大多数病例,尤其是带有ETV6::NTRK3基因融合的病例,表现为缓慢的病程和良好的预后.

科学领域:

在瘤学瘤学.
病理学病理学病理学
遗传学是一个遗传学.

背景情况:

分泌性癌症是一种罕见的,低度的侵袭性乳腺癌.
虽然它在儿科患者中最常见,但它主要在成年人中被诊断出来.
呈现为一个缓慢生长的,无痛的块与非特定的成像发现.

研究的目的:

审查分泌性癌症的关键特征,诊断和预后.
要突出基因基础,特别是ETV6::NTRK3基因融合.
讨论与其他侵入性乳腺癌相关的治疗策略.

主要方法:

组织病理学分析揭示了特征性的分泌物.
基因测试以确定t(12;15)(p13;q25) 转位和ETV6::NTRK3基因融合.
对临床表现,成像和患者结局的审查.

主要成果:

分泌性癌症表现为周期性酸-希夫阳性分泌物和轻度核形.
超过80%的病例都含有ETV6::NTRK3基因融合.
通常表现为一种惰的过程,预后比无特殊类型的侵袭性乳腺癌更好.

结论:

分泌性癌症是一种独特的乳腺癌亚型,预后通常有利.
预后与年轻的年龄,较小的瘤大小和有限的淋巴结参与有关.
治疗方法与其他侵袭性乳腺癌类似,在融合阳性病例中有可能进行向治疗.

关键词:

ETV6::NTRK3的基因融合青少年乳腺癌的乳腺癌.唾液腺类似的瘤这种癌症是分泌性癌瘤.

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