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在抑郁症中使用电治疗期间,关联性记忆障碍的发展轨迹

Yang Ji¹, Wanling Huang¹, Shuang Zheng²

¹Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.

Journal of psychiatric research

|September 11, 2024

概括

电疗法 (ECT) 可以损害关联性记忆 (AM),损伤在早期发展并随着治疗而恶化. 年龄较大的受教育程度较低的女性经历了更快的记忆力下降.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
认知心理学认知心理学

背景情况:

电疗法 (ECT) 是主要抑郁症发作 (MDE) 的重要治疗方法.
记忆障碍,特别是关联性记忆 (AM),是ECT的一个显著的认知副作用.
在ECT治疗期间AM损伤的详细模式尚不清楚.

研究的目的:

调查在ECT期间AM损伤的动态轨迹.
为了确定与AM损伤相关的预测因素.
了解ECT会话数量对记忆结果的影响.

主要方法:

收集了81名接受ECT的MDE患者的纵向数据.
关联性记忆在基线和ECT 1,3,5和8次课程后使用面对面的单词记忆任务进行了评估.
线性混合效应模型,增长混合模型和后勤回归被用于分析.

主要成果:

与基线相比,在ECT期间,关联记忆得分明显较低,在第八次会议后得分最低.
确定了两种不同的AM损伤轨迹:快速 (69.14%的患者) 和缓慢 (30.86%).
高龄,女性性别和较低的教育水平预测了更快速的AM损伤.

结论:

在ECT期间的关联性记忆障碍在早期发展,并随着持续治疗而进展.
识别患有记忆障碍风险较高的患者 (例如,受教育程度较低的老年女性) 可以为临床实践提供信息.
这项研究为了解ECT对记忆的剂量依赖影响提供了证据,并有助于预测患者的结果.

关键词:

联想式记忆是一种联想式的记忆.认知方面的副作用电疗法是一种电疗法.损坏轨迹的发展轨迹大型抑郁症发作主要是因为抑郁症.预测因素是指预测因素.

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