微生物群-肠道-大脑轴:天然抗抑郁药物分子机制
Yitong Lu1, Xiaowen Yu2, Zhongling Wang3
1Department of First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
Phytomedicine : international journal of phytotherapy and phytopharmacology
|September 11, 2024
概括
自然产品可以通过调节微生物群-肠-大脑 (MGB) 轴来治疗严重抑郁症 (MDD). 这些化合物平衡肠道微生物群和神经递质,为新的抗抑郁药物治疗提供了潜力.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 重度抑郁症 (MDD) 是一种严重的心理健康状况,与肠道微生物群 (GM) 失衡有关.
- 微生物群-肠-大脑 (MGB) 轴是影响MDD发展的关键途径.
- 自然产品 (NPs) 显示出对MDD治疗的希望,因为它们的多目标和低毒性.
研究的目的:
- 在MDD开发和主机响应中探索MGB轴.
- 调查NP在调节抗抑郁药效应MGB轴上的机制.
- 确定研究的局限性,并提出未来的MDD治疗策略.
主要方法:
- 对NP,MGB轴和MDD研究的系统文献综述.
- 来自Web of Science,PubMed和ScienceDirect收集的数据截至2024年3月.
- 根据其作用机制对NP进行分类和总结.
主要成果:
- 包括黄类,类和类在内的NP通过调节MGB轴来治疗MDD.
- 机制包括平衡转基因,调节神经递质 (如5-HT,BDNF) 和减少神经炎症.
- NP促进神经可塑性和神经发生,这对抗抑郁药的影响至关重要.
结论:
- 通过MGB轴调节,NP显示出显著的抗抑郁作用.
- 在预防和治疗MDD方面,NP具有临床应用的潜力.
- 进一步的临床前和临床研究对于阐明NP机制和优化MDD疗法至关重要.
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