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Updated: Apr 13, 2026

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在手部糖尿病神经病变或没有糖尿病神经病变的人中,中枢神经和肘部神经的微观结构变化:一个横截面扩散MRI研究

Eva Sierra-Silvestre¹, Robert E Smith², Ricardo J Andrade³

¹School of Health Sciences and Social Work, Griffith University, Brisbane, Australia; Amsterdam Movement Sciences - Program Musculoskeletal Health, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK. Electronic address: https://twitter.com/esiesil.

European journal of radiology

|September 11, 2024

概括

扩散加权成像 (DWI) 检测糖尿病上肢神经的早期变化,甚至在糖尿病多神经病变 (DSPN) 症状出现之前. 在DSPN患者中发现微观结构异常,只影响下肢.

科学领域:

神经成像是一种神经成像.
糖尿病学糖尿病学
神经学神经学

背景情况:

糖尿病神经病变 (DSPN) 是糖尿病的常见并发症,主要影响下肢神经.
扩散加权成像 (DWI) 显示了DSPN患者下肢的神经微结构变化.
上肢神经在糖尿病中使用DWI的微结构变化仍未得到充分研究.

研究的目的:

为了研究和比较糖尿病和没有糖尿病的个体中介和部神经的微观结构.
探索上肢神经在糖尿病神经病变的不同阶段的微观结构变化,包括没有DSPN的,只有下肢DSPN的,以及在上肢和下肢DSPN的.

主要方法:

涉及四组的横截面研究:健康对照组,没有DSPN的糖尿病患者,DSPN (仅脚) 和DSPN (手和脚).
使用扩散加权成像 (DWI) 来计算张量度量 (例如,分数异构性,辐射扩散性) 和非张量度量 (例如,分散性,复杂性).
采用线性混合模型来分析中枢和部神经中的DWI指标,评估远端到近端疾病进展模式.

主要成果:

在DSPN (手和脚) 和DSPN (仅脚) 患者中检测到中枢和腰椎神经的微观结构异常.
在电诊断参数和张量度量之间观察到显著的负相关性.
早期的微观结构变化,可通过非张力度量检测,在患有糖尿病但没有DSPN的个体中存在.

结论:

上肢神经的微观结构变化在糖尿病患者中是可以识别的,无论DSPN状态如何,使用DWI.
这些变化甚至可以在临床症状出现之前被检测出来.
这些发现表明,DWI是检测糖尿病患者上肢神经病变的早期敏感工具.

关键词:

糖尿病糖尿病糖尿病扩散式核磁共振成像 (MRI)手手手的手的手.图像成像是一种成像.神经病变是一种神经病变.上部四肢的上部四肢是什么

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