饮食时间诱导的肠道微生物群的日间振荡调节了类风湿性关节炎的炎症节奏
Fopei Ma1, Zhuang Li2, Haihua Liu3
1Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou 510000, China; Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510000, China.
Cell metabolism
|September 11, 2024
概括
饮食时间通过影响肠道细菌影响类风湿性关节炎 (RA) 节律. 特定的细菌从食物中释放化合物,通过SIRT5-NF-κB通路影响RA炎症,提供新的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 时间生物学 时间生物学
背景情况:
- 类风湿性关节炎 (RA) 是一种具有节律性炎症模式的慢性自身免疫性疾病.
- 驱动RA每日波动的潜在机制尚未完全理解.
- 肠道微生物群表现出白天振荡,可能会影响全身炎症.
研究的目的:
- 研究饮食,肠道微生物群节奏和RA炎症节奏之间的相互作用.
- 为了确定参与调节RA节律的特定微生物通路.
- 探索饮食时间对RA病变的影响.
主要方法:
- 利用原诱导性关节炎 (CIA) 的小鼠模型和人类RA患者队列.
- 采用连续采样技术来监测微生物和分子的每日波动.
- 调查了帕拉巴克特罗伊德分裂症,β-葡萄糖酶和糖在RA炎症中的作用.
主要成果:
- 发现的Parabacteroides distasonis利用β-葡萄糖酶从饮食来源释放糖,受日常营养线索的影响.
- 证明这种微生物-饮食相互作用通过SIRT5-NF-κB轴调节RA炎症节奏.
- 验证了 RA 患者在昼夜周期中这一途径的日间波动.
结论:
- 饮食时间是调节RA炎症节律的关键因素.
- 肠道微生物群,特别是Parabacteroides distasonis,在调解饮食-RA节律相互作用方面发挥着重要作用.
- 这些发现表明,针对 RA 管理的饮食时间和肠道微生物群的新型治疗策略.
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