发现和分析了呼气中的有机成分与支气管切除症之间的关系
Lichao Fan1, Yan Chen1, Yang Chen2
1Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Journal of breath research
|September 11, 2024
概括
使用生物标志物的呼吸试验可以准确地检测支气管切除症 (BE),提供一种低成本的查工具. 这种方法还与BE的严重程度和临床特征相关,有助于个性化管理.
科学领域:
- 肺部医学 肺部医学
- 生物标志物发现发现
- 医学诊断 医学诊断 医学诊断
背景情况:
- 支气管切除症 (BE) 的患病率正在增加,造成严重的健康负担.
- 当前对BE的诊断方法可能不够方便,有效或低成本.
- 迫切需要为BE诊断提供可访问的查工具.
研究的目的:
- 用呼吸学来评估用于诊断BE的呼吸生物标志物 (BBs) 的准确性.
- 探索BBs和BE的临床特征之间的关联.
- 评估基于BBs的模型对BE查和个性化管理的潜力.
主要方法:
- 横截面研究涉及215名BE患者和295名对照.
- 使用高压光子离子化飞行时间质谱分析的呼气样本.
- 机器学习 (ML) 方法用于选择潜在的BB并构建诊断模型.
主要成果:
- 通过ML识别的前十个BB实现了高诊断性能:AUC0.940,灵敏度90.7%,特异性85%,准确率87.4%.
- 确定了BBs和BE严重程度,疾病阶段,血,NTM感染,P. aeruginosa*隔离,涉及的肺叶和肺功能之间的显著关联.
- BBs与BE的各种临床特征有密切的关系.
结论:
- 呼吸生物标志物在诊断支气管切除症时显示出高准确度.
- 呼吸测试为BE查和个性化患者管理提供了一个有希望的新策略.
- BBs与BE的临床特征密切相关,支持其在临床评估中的作用.
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