相关实验视频
Updated: Jun 13, 2025
08:20
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
11.2K
基于人口的抗米勒尔激素参考间隔有助于确定母狗的淋巴状况
Alan J Conley1, Trish Berger2, Casey J Caruso1
11Department of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, CA.
Journal of the American Veterinary Medical Association
|September 11, 2024
概括
为犬类抗穆勒尔激素 (AMH) 建立基于人口的参考间隔有助于评估淋巴状况. 狗的AMH和inhibin-B水平周期性地变化,而前期是最佳采样时间.
科学领域:
- 兽医内分泌学 兽医内分泌学
- 生殖生物学 生殖生物学
- 狗的健康 狗的健康
背景情况:
- 准确解释犬类抗穆勒尔激素 (AMH) 需要建立基于人口的参考间隔 (RIs).
- 了解狗的生殖周期中的荷尔蒙波动对于准确评估淋巴状况至关重要.
研究的目的:
- 为了确定犬类AMH的统计学上有效的,基于种群的参考间隔 (RIs).
- 定义 AMH 和 inhibin-B 在雌性狗 (母狗) 繁殖周期中的周期性变化.
主要方法:
- 采用同类的犬类ELISA测量 AMH 在完整和卵巢切除 (OVH) 狗的血清样本中.
- 从正在进行繁殖管理的母狗取的纵向样本被分析为AMH和inhibin-B (使用异质ELISA).
- 已确立的RI被追溯应用到3,193个临床提交的AMH测试.
主要成果:
- 在完整和OVH母狗中计算了AMH的基于人群的RI.
- 狗的AMH和inhibin-B水平是正相关的,AMH度在前期与前期相比是前期的三倍.
- 追溯分析表明,41%至56%的临床提交在完整的AMH RI或以上,而37%至44%在OVH RI.
结论:
- 在统计学上有效,基于人口的RI为解释母狗的临床AMH结果提供了可靠的基础.
- 在AMH和inhibin-B的循环变化证实了前期是腺状况评估样本采集的最佳时间.
- 预计约有10%或更少的样本提交用于确定淋巴状况预计会产生不确定的AMH结果.
相关概念视频
02:07Oogenesis
63.5K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.5K
01:28Menopause
146
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
146