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相关概念视频

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Cells of the Epidermis01:24

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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A 3D Organotypic Melanoma Spheroid Skin Model
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原发性皮肤黑色素瘤

Jennifer Y Wang1, Susan M Swetter1

  • 1Department of Dermatology/Pigmented Lesion and Melanoma Program, Stanford University Medical Center and Cancer Institute, Stanford, California, USA.

Clinics in dermatology
|September 11, 2024
PubMed
概括
此摘要是机器生成的。

初级皮肤黑色素瘤 (PDM) 是一种罕见的皮肤癌. 尽管模仿转移,PDM有良好的预后,这篇评论涵盖了它的特征和管理.

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科学领域:

  • 皮肤病学 皮肤病学
  • 在瘤学瘤学.
  • 病理学 病理学 病理学

背景情况:

  • 初级皮肤黑色素瘤 (PDM) 是一种罕见的黑色素瘤亚型 (发病率<1%).
  • 皮肤脱皮症起源于皮肤或皮肤下,缺乏表皮连接.
  • 在组织病理学上,PDM类似于皮肤黑色素瘤转移.

研究的目的:

  • 审查PDM的临床和组织病理特征.
  • 讨论PDM作为一个独特的黑色素瘤亚型.
  • 概述PDM目前的临床分期和管理方法.

主要方法:

  • 对PDM的临床和组织病理学数据的文献综述.
  • 对诊断标准和预后因素的分析.
  • 目前阶段化和管理指南的综合.

主要成果:

  • 在没有表皮连接的情况下呈现PDM,模仿转移.
  • 尽管PDM与转移具有相似的组织学,但其预后是有利的.
  • 区分PDM与转移对于适当的管理至关重要.

结论:

  • 晚期黑色素瘤是一种独特的黑色素瘤亚型,具有独特的临床和病原学特征.
  • 准确的诊断和分期对于最佳的患者结果至关重要.
  • 进一步的研究可能会阐明PDM的特定治疗策略.