癌症和补充性腺炎
Philip R Cohen1, Rena A Cohen-Kurzrock2, Ryan R Riahi3
1Department of Dermatology, UC Davis Medical Center, University of California, Davis, Sacramento, California, USA; Touro University California College of Osteopathic Medicine, Vallejo California, USA.
Clinics in dermatology
|September 11, 2024
概括
患有性腺炎 (HS) 的患者面临更高的癌症风险,包括在HS病变中的状细胞癌 (SCC). 由于潜在的转移和复发风险,早期检测和治疗至关重要.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
背景情况:
- 补腺炎 (HS) 是一种慢性炎症性皮肤疾病.
- 患有HS的患者患有各种癌症的风险增加,包括血液恶性瘤,固体瘤,特别是在HS病变中产生的皮肤状细胞癌 (SCC).
研究的目的:
- 审查 hidradenitis suppurativa 和癌症发展之间的关联.
- 为了确定与HS相关的恶性瘤的风险因素,临床表现和诊断考虑.
- 讨论潜在的治疗策略和预后.
主要方法:
- 对调查HS和癌症的研究进行文献综述.
- 分析风险因素,包括吸烟,病变持续时间和特定治疗方法.
- 检查诊断挑战和差异诊断.
主要成果:
- 皮肤状细胞癌 (SCC) 是与HS相关的最常见的恶性瘤,特别是在患有长期严重的部/外部疾病的高加索男性中.
- 危险因素包括吸烟,延长HS持续时间,某些基因皮肤病和副瘤综合征.
- 人类乳头瘤病毒 (HPV) 可能涉及;由于转移和复发,预后往往不好.
- HS病变可以模仿皮肤转移,反之,癌症可以呈现为HS病变.
结论:
- 对于HS患者,需要对恶性瘤进行警监测,特别是那些具有危险因素的患者.
- 迅速评估新的,快速生长的或耐治疗的HS病变对于早期癌症诊断至关重要.
- 需要对HPV疫苗接种和新型针对性治疗HS相关的SCC进行进一步的研究.
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