相关实验视频

Updated: Jun 13, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

400

在系统性硬化症模型中,IL-21驱动皮肤和肺炎和纤维化

In Gyu Um1, Jin Seok Woo2, Young Joon Lee1

  • 1Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea; Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.

Immunology letters
|September 11, 2024
PubMed
概括

干白素-21 (IL-21) 通过增加纤维化相关基因和改变T细胞群来促进全身性硬化 (SSc). 阻断IL-21在小鼠模型中降低了SSc的严重程度,表明IL-21是治疗目标.

关键词:
介质蛋白-21 (IL-21) 介质蛋白-21 (IL-21) 介质蛋白-21 (IL-21) 介质蛋白-21 (IL-21) 介质蛋白-21) 介质蛋白-21 (IL-21) 介质蛋白-21 (IL-21) 介质蛋白-21 (IL-21) 介质蛋白-21 (IL-21) 介质蛋白-21肺部纤维化 肺部纤维化信号传感器和转录激活器 (STAT) 3 信号传感器和转录激活器 (STAT) 3皮肤纤维化 皮肤纤维化系统性硬化症 (SSc) 是一种疾病.

更多相关视频

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses08:16

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

Published on: July 7, 2017

7.4K
Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

8.1K

相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
961
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
8.7K