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围产期暴露于Bisphenol F对后代小鼠的神经毒性影响

Siming Huo¹, Bo Li¹, Jiayu Du¹

¹Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.

Environmental pollution (Barking, Essex : 1987)

|September 11, 2024

概括

围产期暴露于双F (BPF) 阻碍了雄性小鼠的生长和神经发育,这表明BPF可能不是双A (BPA) 的安全替代品. 这凸显了对内分泌干扰化学物质 (EDC) 和神经发育的担忧.

科学领域:

环境毒理学环境毒理学
神经科学是一个神经科学.
发展生物学发展生物学

背景情况:

双是影响激素活性的内分泌干扰化学物质 (EDC).
双F (BPF) 是双A (BPA) 的常见替代品.
胚胎发育期间EDC诱导的免疫干扰与神经发育障碍有关.

研究的目的:

研究围产期双F (BPF) 暴露对后代小鼠的神经毒性影响.
评估BPF对生长和神经发育的影响,特别是在男性中.

主要方法:

小鼠在怀孕和哺乳期 (产前期) 暴露于BPF.
评估了后代的生长和神经发育.
对暴露于高剂量的BPF的男性后代的大脑进行了转录组分析.

主要成果:

周产期BPF暴露会影响后代的生长和神经发育,男性的影响更大.
转录组分析显示,男性后代大脑与氧化应激,炎症和免疫失调有关.
暴露于BPF对男性后代的神经发育产生了负面影响.

结论:

周产期BPF暴露会导致男性后代的神经发育障碍.
这些障碍与氧化应激,炎症和免疫失调有关.
BPF可能不是BPA的安全替代品,需要监管重新评估.

关键词:

双二醇 F 是一种双二醇破坏内分泌的化学物质破坏内分泌的化学物质它具有神经毒性,具有神经毒性.他们有后代,有后代的后代.周产期的周产期的

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