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用于癌症免疫治疗的免疫调节金属基生物材料

Kangzhi Yuan¹, Cai Zhang¹, Xinlu Pan¹

¹State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China.

Journal of controlled release : official journal of the Controlled Release Society

|September 11, 2024

概括

基于金属的生物材料通过增强抗瘤免疫反应,在癌症免疫治疗中表现有前途. 这些材料可以提高癌症免疫治疗的有效性,克服像低响应率这样的局限性.

科学领域:

生物医学工程生物医学工程
免疫学免疫学免疫学
材料科学材料科学材料科学

背景情况:

癌症免疫疗法利用患者的免疫系统对抗癌症,但面临着低响应率的挑战.
基于金属的生物材料正在成为免疫调节剂,以增强抗瘤免疫力和逆转免疫抑制.
这些材料提供了一种潜在的策略,可以改善癌症免疫疗法的结果,而不会产生显著的有毒副作用.

研究的目的:

审查生物活性金属元素的分类和免疫调节机制.
讨论来自各种金属 (Al,Mn,Au,Ca,Zn,Fe,Mg,Cu) 的生物材料的免疫调节作用.
提供金属基生物材料在增强癌症免疫治疗中的概述,并概述未来的前景和挑战.

主要方法:

关于金属基生物材料及其免疫调节功能的文献综述.
生物活性金属元素根据其特性进行分类.
免疫调节机制和癌症免疫治疗中的应用概述.

主要成果:

基于金属的生物材料可以调节免疫反应以增强抗瘤作用.
各种金属如,,黄金,,,铁,和铜都表现出免疫调节的特性.
这些材料在提高癌症免疫疗法的疗效方面已经显示出潜力.

结论:

基于金属的生物材料代表了一种有希望的方法,通过调节免疫系统来增强癌症免疫疗法.
对它们的机制和应用进行进一步的研究对于临床转化至关重要.
解决与这些材料相关的挑战将是实现其在癌症治疗中的全部潜力的关键.

关键词:

抗瘤免疫反应抗瘤免疫反应癌症免疫疗法癌症免疫疗法免疫调节剂是一种免疫调节剂.基于金属的生物材料

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