在严重抑郁症和双相情感障碍中,默认模式网络功能障碍的共同和独特模式:比较的元分析
Lisha Zhang1, Kun Qin2, Nanfang Pan3
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China.
Journal of affective disorders
|September 11, 2024
概括
大型抑郁症 (MDD) 和双相情感障碍 (BD) 显示出不同的默认模式网络 (DMN) 功能连接模式. 这些DMN静止状态功能连接 (rsFC) 的差异可能有助于区分这些情绪障碍.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 重度抑郁症 (MDD) 和双相情感障碍 (BD) 与默认模式网络 (DMN) 功能障碍有关.
- 之前在MDD和BD的DMN中关于静止状态功能连接 (rsFC) 的发现是不一致的.
- 关于MDD和BD之间DMN rsFC的具体相似之处和差异的知识有限.
研究的目的:
- 调查和比较默认模式网络 (DMN) 休息状态功能连接 (rsFC) 模式在患有严重抑郁症 (MDD) 和双相情感障碍 (BD) 的患者中.
- 在MDD和BD之间识别不同的或常见的DMN rsFC异常.
- 通过功能解码来探索观察到的大脑异常的心理生理学基础.
主要方法:
- 基于种子的DMN rsFC研究的voxel-wise元分析使用基于种子的d绘图与对象图像 (SDM-PSI) 软件进行.
- 在MDD和BD中分别分析了DMN rsFC,随后进行了结合和疾病之间的比较分析.
- 使用功能解码来解释已识别的大脑变化的功能意义.
主要成果:
- 分析包括34项MDD (1316名患者) 和22项BD (1059名患者) 的研究,与健康对照进行比较.
- 患有MDD的患者表现出DMN与前膜系统的超连接性,以及与叶和后带带皮层的低连接性.
- 患有BD的患者表现出DMN与双边前皮质的连接性增加,以及与前额叶皮质和中圈的连接性减少. 在MDD和BD之间没有发现常见的DMN rsFC异常. 与BD患者相比,MDD患者在特定的左前和状回旋区域表现出DMN超连接性. 功能解码将这些变化与行动和感知领域联系起来.
结论:
- 在MDD和BD中存在不同的DMN功能障碍模式,有助于更好地了解它们的神经基质.
- 这些已识别的DMN rsFC变化可以作为区分MDD和BD的潜在生物标志物.
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