如果你吃纳米塑料呢? 在胃肠道消化过程中模拟纳米塑料命运
Maria Hayder1, Annemarie P van Wezel2, Gert-Jan M Gruter3
1Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098XH, Amsterdam, the Netherlands.
Chemosphere
|September 11, 2024
概括
纳米塑料 (NP) 在人体胃肠道 (GIT) 中聚集,增加它们的尺寸. 这项研究表明,消化酶导致NP形成脆弱的团块,可能限制肠道吸收.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 微塑料和纳米塑料越来越多地出现在食品和饮料中.
- 人的胃肠道 (GIT) 中纳米塑料 (NP) 的行为和命运尚不清楚.
- 在消化过程中纳米塑料的尺寸变化可能会影响肠道吸收.
研究的目的:
- 在模拟体外胃肠道消化 (GID) 过程中研究聚合物纳米颗粒的聚合行为.
- 了解纳米塑料和消化酶之间的相互作用.
- 评估物理化学特性如何影响纳米塑料在GIT中的命运.
主要方法:
- 模拟的在体外胃肠道消化 (GID) 的聚合物纳米颗粒具有不同的特性.
- 使用专门的分析技术对纳米粒子聚合物的分析.
- 研究纳米塑料和消化酶之间的相互作用.
主要成果:
- 更小的纳米塑料表现出更大的聚合,缩小了整体颗粒大小分布.
- 不同聚合物的纳米颗粒显示异构聚合.
- 消化酶与纳米塑料相互作用,形成大而脆弱的聚合物.
- 即使是具有酸功能的纳米塑料在酶的存在下也聚集在一起.
结论:
- 胃肠道消化显著增加了所摄入的纳米塑料的有效尺寸.
- 这种尺寸增加可能会降低纳米塑料穿越细胞膜的潜力.
- 该研究解决了关于纳米塑料口服吸收的关键知识差距,并为其表征提供了基础.
更多相关视频
08:21Forming Micro-and Nano-Plastics from Agricultural Plastic Films for Employment in Fundamental Research Studies
Published on: July 27, 2022
4.1K
10:20In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids
Published on: November 18, 2022
2.5K
相关概念视频
What is Monogastric Digestion?
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
Bioplastics
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
Microbial Bioremediation of Plastics
Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...
