和其DNA甲基化档案与心房动之间存在因果关系
Zequn Zheng1, Haohao Chen2, Yanbin Chen3
1Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China; Clinical Medical Research Center, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China; Human Phenome institute of SUMC, Guangdong Engineering Research Center of Human Phenome, chemistry and Chemical Engineering Guangdong Laboratory, Shantou, Guangdong, China.
焦点与海马硬化症显著增加了心房动的风险. 这突显了神经与心脏之间的联系,并表明特定的甲基化位点可以预测AF易感性.
科学领域:
- 神经心脏病学 神经心脏病学
- 遗传学 遗传学 是一个
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 和心房动 (AF) 之间的关系正在出现,但尚未完全理解.
- 这是一个很棒的节目,这是一个很棒的节目.
研究的目的:
- 调查类型和AF之间的遗传相关性.
- 使用孟德尔随机化 (MR) 探索和AF之间的双向因果关系.
- 为了确定连接和AF风险的表观遗传因素.
主要方法:
- 分析了10种类型和AF的全基因组关联研究 (GWAS) 数据.
- 联系不平衡得分回归 (LDSC) 和MR评估了遗传相关性和因果关系.
- 全表观基因组关联研究 (EWAS) 的数据用于表观基因MR分析.
主要成果:
- 在四种类型和AF之间发现了显著的遗传相关性.
- 带有海马硬化 (FE与HS) 的焦点性与增加的AF风险 (OR = 1.046) 有因果关系.
- 特定的CpG甲基化位点 (cg06222062, cg08461451, cg10541930) 被确定为潜在的表观遗传媒介.
结论:
- 与HS相结合的FE显著增加了AF风险,强调了神经与心脏的联系.
- 建议对患者进行心脏监测.
- 已识别的甲基化CpG位点可以作为AF风险的生物标志物.
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