红茶的多重向作用可能会防止缺血性中风引起的神经缺陷和内皮功能障碍
L Pretorius1, K S Ross1, C Smith1
1Experimental Medicine Research Group, Division of Internal Medicine, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.
Journal of ethnopharmacology
|September 11, 2024
概括
红 (Aspalathus linearis) 提取物在斑马鱼中风模型中表现出神经保护作用和改善血管健康. 这项研究突出了红作为中风补充疗法的潜力,通过减少血栓形成和正常化神经标志物来治疗中风.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 神经科学是一个神经科学.
- 心血管研究研究心血管研究
背景情况:
- 在历史上,土著社区一直在使用Aspalathus linearis (rooibos) 用于医疗目的,包括治疗高血压.
- 红茶表现出抗氧化特性,并显示出潜在的神经保护作用.
- 高血压会对内皮细胞产生负面影响,这表明红茶在血管健康和中风预防方面发挥了作用.
研究的目的:
- 调查未发酵红豆提取物对血管健康的潜在益处.
- 在模拟缺血性中风的斑马鱼幼虫模型中评估红豆的疗效.
主要方法:
- 在斑马鱼幼虫中使用ponatinib暴露诱导中风.
- 幼虫被处理成未发酵红茶 (GreenOxithinTM) 的水性乙醇提取物.
- 通过监测运动,血栓形成,氧化还原状态和特定蛋白质表达 (TH,NeuroD1,ZO-1,claudin-5,VE-cadherin) 来评估血管健康和神经效应.
主要成果:
- 红茶治疗显著减少了血栓形成,并预防了中风引起的运动缺陷.
- 它使神经元蛋白质表达 (NeuroD1,TH) 的中风引起的变化正常化,这表明神经保护.
- 红茶防止了紧结蛋白ZO-1和调节的Claudin-5和VE-cadherin的减少,这表明内皮完整性得到改善,血管功能障碍减少.
结论:
- 在斑马鱼中风模型中,未发酵的红茶显示出多个目标的益处,支持其作为补充性中风治疗的潜力.
- 这些发现阐明了潜在的作用机制,包括抗氧化和神经保护作用.
- 需要进一步的研究来证实红豆在哺乳动物系统中的生物可用性和有效性.
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