完善加拿大的军种/传播性结核病的定义
Yiming Huang1, Richard Long1, Giovanni Ferrara1
1Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
概括
这项研究评估了传播性结核病 (DTB) 的定义,发现结合严格和多站点标准可以提高报告的一致性. 这两种定义都表明DTB患者的治疗结果较差,死亡风险更高.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 传播性结核病 (DTB) 的定义影响了诊断和报告.
- 有限的证据支持目前对DTB的"多站点"定义.
研究的目的:
- 为了产生证据支持使用"多站点"的传播性结核病 (DTB) 的定义.
- 为了比较严格和多站点DTB定义之间的治疗结果和报告要求.
- 为了确定DTB患者致命结局的风险因素.
主要方法:
- 分析了加拿大连续诊断结核病 (TB) 患者的15年人口基队列.
- 应用了两个不同的DTB定义 (严格和多站点).
- 多变量逻辑回归在DTB中确定了结核病相关死亡的风险因素.
主要成果:
- 在2877名结核病患者中,110名 (3.8%) 符合严格的DTB定义,168名 (5.8%) 符合多站点定义.
- 在所有DTB患者中,只有不到一半被通知为DTB患者,只有23.7%被加拿大公共卫生署分类为DTB患者.
- 符合DTB定义的患者的治愈率较低,死亡率较高;死亡的风险因素包括晚年,加拿大出生,中枢神经系统参与和艾滋病毒同时感染.
结论:
- 结果支持将严格和多站点定义结合起来,以实现DTB报告的一致性.
- 综合定义有助于对传播性结核病进行可比性调查.
- 标准化DTB定义对于准确的公共卫生监测和研究至关重要.
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