母亲的小助手变成了敌人:阿尔普拉佐拉姆的使用,滥用和滥用
Astrid M Cardona-Acosta1, Noelle Meisser1, Nathan I Vardeleon1
1Department of Psychological and Brain Sciences, and Institute for Neuroscience, Texas A&M University, College Station, TX 77843, USA.
Progress in neuro-psychopharmacology & biological psychiatry
|September 11, 2024
概括
滥用二,包括阿尔普拉佐拉姆,带来严重的风险,如成和放大阿片类药物效应,导致过量死亡. 更多的研究对于了解这些危险的药物相互作用及其后果至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 二是有效的短期焦虑治疗,但携带诸如依赖和放大阿片类药物效应等风险.
- 不适当使用二,包括阿尔普拉佐拉姆 (Xanax®),正在全球范围内增加,导致严重的公共卫生问题.
- 二类药物与大约30%的阿片类药物过量死亡有关,这凸显了联合使用的危险性.
研究的目的:
- 审查目前关于二胺使用和滥用的知识,专注于阿尔普拉佐拉姆.
- 检查汽类药物,特别是阿尔普拉佐拉姆和阿片类药物之间的相互作用.
- 讨论风险人群中容忍,依赖和滥用责任的机制.
主要方法:
- 临床和临床前研究的文献综述.
- 对二甲和阿片类药物同时使用的数据的分析.
- 探索与药物相互作用和依赖有关的药理机制.
主要成果:
- 尽管使用和风险广泛,但对二胺-阿片类药物相互作用的研究是有限的.
- 阿尔普拉佐拉姆经常被处方和滥用,经常与阿片类药物一起滥用,增加了过量服用的风险.
- 了解容忍,依赖和滥用责任需要进一步调查.
结论:
- 目前对二胺-阿片类药物相互作用的理解不足.
- 进一步的研究是必不可少的,以解决使用二胺和阿尔普拉佐拉姆的短期和长期后果,特别是与阿片类药物.
- 突出物质使用障碍的人群中的风险对于公共卫生干预至关重要.
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