补充剂对成年人脂质特征的影响:随机对照试验的系统综述和元分析
Mohamed J Saadh1, Abdulrahman Qais Khaleel2, Muna S Merza3
1Faculty of Pharmacy, Middle East University, Amman 11831, Jordan.
Prostaglandins & other lipid mediators
|September 11, 2024
概括
补充剂在成人中显著降低了非常低密度脂蛋白 (VLDL) 胆固醇. 然而,它对其他脂质资料,包括总胆固醇,甘油三,LDL-C和HDL-C,表现出有限的影响,这表明需要进一步研究.
科学领域:
- 营养生物化学 营养生物化学
- 心血管疾病风险因素 心血管疾病风险因素
- 人类健康与营养
背景情况:
- 脱脂症是心血管疾病 (CVD) 的一个主要危险因素.
- 饮食对脂质谱的影响仍在争论中.
- 现有的关于和成人脂质配置文件的研究产生了不一致的结果.
研究的目的:
- 为了评估补充剂在修改成人脂质谱中的有效性.
- 分析对总胆固醇 (TC),甘油三 (TG),LDL-C,VLDL和HDL-C的影响.
主要方法:
- 在主要数据库 (Scopus,PubMed,Web of Science,Google Scholar) 进行系统的文献搜索,截至2024年7月.
- 包括25个随机对照试验 (RCT) 从最初的1205项研究中.
- 随机效应的元分析,以组合加权平均差异 (WMD) 和95%置信区间 (CI).
主要成果:
- 补充剂显著降低了非常低密度脂蛋白 (VLDL) 胆固醇 (WMD: -1.53; 95% CI: -2.86, -0.20).
- 在甘油 (TG),总胆固醇 (TC),LDL-C或HDL-C水平上没有观察到显著的变化.
- 对于TG,TC,LDL-C和HDL-C的个别研究结果显示出相当大的异质性.
结论:
- 补充剂可以有效降低VLDL胆固醇.
- 观察到对其他关键脂质参数的影响有限.
- 进一步的大规模全球RCT是必要的,以充分理解在脂质代谢中的作用.
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