迷幻药辅助治疗治疗焦虑,抑郁和存在困境的人与危及生命的疾病
Sivan Schipper1, Kabir Nigam2, Yasmin Schmid3
1Department of Medicine, Spital Uster, Uster, Switzerland.
The Cochrane database of systematic reviews
|September 11, 2024
概括
迷幻药辅助疗法可以减少患有危及生命的疾病的患者的焦虑和抑郁. 虽然一般耐受性很好,但证据的确定性低至非常低,需要进一步研究.
科学领域:
- 精神病学和心理学 精神病学和心理学
- 临床试验 临床试验
- 药理学 药理学是指药理学的学科.
背景情况:
- 迷幻药辅助疗法涉及对迷幻药物的监督使用.
- 假设在绝症患者中减轻焦虑,抑郁和存在的痛苦.
- 物质在很大程度上是非法的,并带有潜在的风险.
研究的目的:
- 为了评估心理治疗辅助疗法的疗效和安全性,与安慰剂或活性比较剂相比.
- 专注于治疗患有危及生命的疾病的患者的焦虑,抑郁和生存困境.
主要方法:
- 随机对照试验 (RCT) 的系统审查.
- 搜索了多个数据库 (CENTRAL,MEDLINE,Embase) 和试验登记册.
- 包括有准备性和整合性治疗课程的研究.
主要成果:
- 六项研究 (140名参与者) 评估了psilocybin,LSD和MDMA.
- 经典迷幻药可能会减少焦虑和抑郁 (低确定性证据).
- 关于MDMA和存在困境的证据非常不确定;没有报告严重不良事件.
结论:
- 在危及生命的疾病中,用经典迷幻药物进行心理辅助疗法显示出潜在的焦虑,抑郁和生存困境.
- 疗法似乎耐受良好,但证据确定性低至非常低.
- 需要进一步研究更大的样本大小;存在监管限制.
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