胎儿体重增长轨迹和儿童发育:基于人口的队列研究
Xinmei Chen1, Hongxiu Liu1, Aifen Zhou2
1Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Science bulletin
|September 11, 2024
概括
胎儿生长轨迹 (FGTs) 预测儿童发育,并揭示代谢变化. "早期加速与晚期中等增长"的FGT似乎是最佳的,与更好的结果和更少的风险有关.
科学领域:
- 周围生理学 周围生理学
- 发育儿科 发育儿科
- 代谢学 代谢学 代谢学
背景情况:
- 胎儿生长轨迹 (FGT) 是子宫内健康的关键指标.
- 了解FGT对早期发育的预测能力对于识别潜在的健康风险至关重要.
- 与FGT相关的子宫内代谢适应需要进一步研究.
研究的目的:
- 调查FGT作为早期儿童发育的预测因素.
- 探索FGTs和子宫内代谢变化之间的联系.
- 为了确定生命早期健康结果的最佳和次优FGT.
主要方法:
- 使用无监督机器学习来定义FGT.
- 儿童的神经发育,人体测量和呼吸系统的结果被评估到6岁.
- 对一个子组进行了带血代谢学分析,以确定FGTs的代谢特征.
主要成果:
- 确定了六种不同的FGT,包括"早期加速与晚期中等增长"作为潜在的最佳.
- 最佳的FGT与卓越的精神运动,精神发展,智商,肺功能以及减少行为/呼吸问题有关.
- 低于最佳的FGT (早期减速,晚期减速,早期加速) 与不良的神经发育,肺功能,自闭症症状和肥胖风险有关.
- 氨基酸和脂质代谢的代谢变化与特定的FGTs有关.
结论:
- 胎儿生长轨迹是早期生命发展的重要预测因素.
- FGTs表明子宫内适应性代谢过程.
- 识别最佳和次优FGT为早期检测和干预胎儿起源条件提供了潜在的潜力.
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