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相关概念视频

Dosage Regimen: Individualization01:24

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Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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肺SBRT:基于目标大小的剂量梯度优化.

Kathryn Benner1, Justin Roper1, Aparna H Kesarwala1

  • 1Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists
|September 11, 2024
PubMed
概括
此摘要是机器生成的。

更的正常组织客观下降值可以改善体内立体辐射疗法 (SBRT) 中小型和中型肺瘤的剂量梯度. 然而,较大的目标没有显著改善,突出显示需要针对大小进行特定优化,以最大限度地减少剂量泄漏.

关键词:
符合性指数是指符合性指数.下降的结束时间.肺 肺 肺 肺 肺 肺 肺目标是正常组织的正常组织.刻板印象性的身体辐射疗法

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科学领域:

  • 辐射瘤学 辐射瘤学
  • 医学物理 医学物理
  • 放射治疗规划 放射治疗规划

背景情况:

  • 肺癌的立体体辐射疗法 (SBRT) 需要精确的剂量输送.
  • 优化剂量梯度对于节省正常组织而有效治疗目标至关重要.
  • 肺SBRT中目标大小和剂量梯度优化之间的关系需要进一步研究.

研究的目的:

  • 为了研究不同规划目标体积 (PTV) 大小的正常组织目标 (NTO) 掉落值如何影响剂量梯度.
  • 为了确定最佳的NTO设置,以实现的剂量梯度作为目标大小的函数.

主要方法:

  • 分析了68名患有PTV的肺SBRT患者,分为小,中,大组.
  • 使用逐渐的NTO掉落值 (0.1-0.5mm-1),生成体积调制弧线疗法 (VMAT) 计划.
  • 使用AcurosXB算法进行了剂量计算,统计分析评估了符合指数 (CI50%),最大剂量 (Dmax) 和监测单位 (MU) 的差异.

主要成果:

  • 在所有目标尺寸 (p < 0.05) 中,的NTO掉落值显著增加了Dmax和MU.
  • 对于小 (0.3 mm-1) 和中 (0.2 mm-1) 目标,以及较的落差值 (p < 0.05),观察到 CI50% 的改善.
  • 大目标没有显示显著的CI50%差异与不同的掉落值,这表明随着目标大小的增加,其重要性正在下降.

结论:

  • 较小的肺标受益于SBRT中较的NTO掉落值,导致尽管增加了Dmax和MU,但剂量一致性得到改善.
  • 对于较大的目标,NTO掉落值对剂量一致性的影响较小.
  • 根据目标尺寸调整NTO掉落值对于优化肺SBRT计划和最大限度地减少辐射剂量到周围健康组织至关重要.